NDL Pro-Health Articulations is a dietary supplement formulated from nutrients such as manganese, which contributes to maintaining healthy bones under normal conditions, and copper, which contributes to the maintenance of connective tissue under normal conditions Vitamin C contributes to the normal formation of collagen for the normal functioning of bones and the normal functioning of cartilage.
Turmeric Longa, Type II Collagen, Hyaluronic Acid and Lipinova- 11TG R with high content of Omega 3 fatty acids.
Contains Hesperidin*, a flavonoid present in high concentrations in citrus fruits, with antioxidant and anti-inflammatory properties.
Certain physical activity along with getting older have their effects on articulations, tendons and ligaments. NDL Pro-Health Articulations combines the properties of the highest quality ingredients in an easy-to-take dietary supplement to allow you to access all its benefits.
Its formula is fortified with specific ingredients:
Collagen is very important for the elasticity of various tissues, where it plays a fundamental structural role.
Curcuma Longa has a preventive effect on oxidative damage.
Lipinova-11TG R is a unique ingredient obtained from fish oils that supports the body's own ability to resolve inflammation.
Hyaluronic acid is found naturally in many tissues and fluids but is most abundant in articular cartilage and synovium.
Synovium is a liquid that fills the joint cavities with its presence and is characterized by the presence of high concentrations of hyaluronic acid, glycoproteins and ions.
All NDL Pro-Health products meet the strictest quality criteria.
Take one capsule per day. Take with a glass of water.
INGREDIENTS |
MG/CAP |
FUNCTIONALITY |
VNR |
Turmeric Extract |
100 |
Anti-inflammatory and antioxidant |
* |
Collagen type II |
40 |
Joint recovery |
* |
Lipinova – 11TG |
40 |
Joint and muscle recovery |
* |
Vitamin C |
40 |
Reduces tiredness and fatigue |
50% |
Manganese sulphate |
0.923 |
Bone maintenance |
15% |
Copper sulphate |
0.419 |
Anti-inflammatory |
17% |
Hesperidin |
50 |
Antioxidant and anti-inflammatory |
* |
Hyaluronic acid |
33.33 |
Joint recovery |
* |
NDL PRO HEALTH Articulations do not contain any substances included in the WADA prohibited list either in their composition or in the manufacturing process.
95% TURMERIC: Intense physical exercise, especially high intensity exercise with a high number of eccentric contractions, leads to muscle damage (EIMD, “exercise-induced muscle damage”) and the subsequent development of muscle numbness (DOMS, “Delayed Onset Muscle Soreness Muscle damage induces an inflammatory response associated with a loss in muscle strength, loss of mobility, swelling, numbness, and an increase in the amount of muscle proteins in the blood (such as creatine kinase, CK). This is followed by an inflammatory cascade trigger where pro-inflammatory cytokines increase, the accumulation of advanced glycosylation end products (AGEs) and reactive oxygen species (ROS) occurs (5). Although this is part of recovery and the natural response to exercise, it can cause fatigue and decreased athletic performance (6). Addressing these problems may be especially important in sports where muscle soreness could hinder performance in subsequent routines (for example, sports competitions extended over time).
Curcumin (a natural polyphenol and the main constituent of the spice turmeric) has recently attracted the focus of various studies focused on recovery after exercise (7–9) thanks to its anti-inflammatory and antioxidant benefits. These studies show improvement in the measures of pain and sensitivity (discomfort) perceived by the athletes themselves, evidencing a reduction in muscle damage and decreasing markers of inflammation, increasing antioxidant capacity, decreasing markers of oxidative stress, AGEs. and reducing DOMs (5, 7, 9, 10).
TYPE II COLLAGEN Excessive mobility, as well as repeated loading on joints, generate damage that comes mainly from the degradation of cartilage, of which collagen is the main component(11). Type II collagen is a major component of cartilage (12). During intense exercise routines, the collagen in the joints degrades, which affects the physical properties of the joints, leading to inflammation and subsequent pain. The released collagen fragments also encourage the immune system to recognise the body's own collagen as a potentially harmful component and actively attack it.
This feeds back into the cycle of collagen destruction, increasing inflammation and joint pain as well as being directly related to the high incidence of osteoarthritis and other autoimmune diseases in athletes (13). Within this context, a chronic source of hydrolysed collagen in nutritional supplements has been shown to be highly beneficial for joint care, benefiting the replacement of degraded collagen during exercise routines(14–16). In any case, the immune response activated during the collagen degradation processes associated with exercise continues to represent a threat to athletes. This is the reason behind Cantabria Labs recommendation of a strategy that protects the collagen of the joints instead of replacing it once it has already been degraded. This involves the addition of a source of natural collagen specifically in its native form (B-2Cool).
When ingested, this type of collagen reduces autoimmune reactions against its own collagen (induction of oral tolerance), reducing its destruction. This mechanism of action has shown very promising results in preclinical and clinical trials, while also reducing different parameters associated with pain (17, 18).
Therefore, not only would joint pain be actively treated, but it would also ensure the long-term health of athletes protecting their joints.
DIFFERENCE TYPE I COLLAGEN AND TYPE II COLLAGEN
- Type I collagen: This type of collagen is the most abundant in the human body and is found in the skin, bones, tendons, ligaments and other connective tissues. It provides strength and support to these tissues and is important for the elasticity and strength of the skin.
- Type II Collagen: This type of collagen is found in cartilage, which is a connective tissue that helps cushion joints and bones Type II Collagen provides strength and elasticity to cartilage and is important for its ability to absorb shock and support the weight of the body.
To sum up, the main difference between type I and type II collagen is their location in the body and their function.
While type I collagen is important for the strength and elasticity of skin, bones and connective tissues, type II collagen is essential for the health and function of cartilage, which cushions joints and bones.
LIPINOVA-11TG – SPMs (ProResolve SPMs): Exhaustive training leads to muscle damage and inflammation that should be resolved correctly as part of the natural recovery process from intense exercise (6). If this does not occur, chronic inflammation, the continued production of ROS, the appearance of fatigue, pain, and the early development of autoimmune diseases such as different types of arthritis in the long term occur. The so-called pro-resolving mediators (SPMs) intervene in the correct resolution of inflammation (19). This formula incorporates a mixture of omega-3 polyunsaturated fatty acids (including EPA -eicosapentaenoic acid- and DHA -docosahexaenoic acid-), necessary for the synthesis of SPMs and whose effectiveness in the form of supplements has been demonstrated in clinical studies (20, 21).
100% VITAMIN C: Playing a mainly antioxidant role, it also promotes collagen synthesis, iron absorption (counteracting athlete's anaemia), helps control ROS levels, inflammation and reduce tiredness and fatigue (4, 22–24).
MANGANESE: Protects joint wear and tear, due to being essential for cartilage repair (25, 26) and bone maintenance, improving bone density (27).
COPPER: Copper at low concentrations improves joints, acting at the level of both cartilage and bone. It facilitates the regeneration of chondrocytes, reduces inflammation and the likelihood of osteoarthritis (25, 28).
HESPERIDIN: Flavonoids are bioactive substances found mainly in fruits and vegetables, with more than 15,000 molecules identified within this family (29). One of the best-known flavonoids is hesperidin, which is present in high concentrations in citrus fruits. When hesperidin reaches the intestine, the bacterial flora converts it into hesperetin, which is the main metabolite of hesperidin (30). Previous studies have shown that hesperidin has various pharmacological activities such as anti-atherogenic, antihyperlipidemic, antidiabetic, venotonic, cardioprotective, anti-inflammatory and antihypertensive (neurological, cardiovascular, insulin-sensitizing) activities due to its antioxidant and anti-inflammatory properties. Hesperidin inhibits the secretion of pro-inflammatory cytokines such as TNFα, IL-6, IFN-γ and IL-2 (31–34). The intake of hesperidin has also been demonstrated to be extremely safe (35), modulating leukocyte gene expression, enhancing its antioxidant and inflammatory profile (36–38).
HYALURONIC ACID: A component of the synovial fluid of the joint, the extracellular matrix of cartilage and tendons (39), taking it orally in supplement form would function in a similar way as described by collagen in its native state, actively reducing joint pain and preventing the appearance of autoimmune arthritis (40–42)
NDL PRO HEALTH Articulations do not contain any substances included in the WADA prohibited list in either their composition or during their manufacturing process.
Do not exceed the expressly recommended daily dose. Nutritional supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle It should not be used by pregnant or lactating women or anyone under 18 years of age. Keep out of the reach of children. Store in a cool, dry place away from light and heat sources. The indicated expiry date refers to the product stored correctly in its original packaging.
1. Feeley BT, Kennelly S, Barnes RP, Muller MS, Kelly BT, Rodeo SA, et al. Epidemiology of National Football League Training Camp Injuries from 1998 to 2007. Am J Sports Med. 1 de agosto de 2008;36(8):1597-603.
2. Hootman JM, Dick R, Agel J. Epidemiology of Collegiate Injuries for 15 Sports: Summary and Recommendations for Injury Prevention Initiatives. J Athl Train. 2007;42(2):311-9.
3. Hawkins RD, Hulse MA, Wilkinson C, Hodson A, Gibson M. The association football medical research programme: an audit of injuries in professional football. Br J Sports Med. 1 de febrero de 2001;35(1):43-7.
4. Shaw G, Lee-Barthel A, Ross ML, Wang B, Baar K. Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis. Am J Clin Nutr. 1 de enero de 2017;105(1):136-43.
5. Effects of Curcumin Supplementation on Inflammatory Markers, Muscle Damage, and Sports Performance during Acute Physical Exercise in Sedentary Individuals [Internet]. [citado 31 de octubre de 2022]. Disponible en: https://www.hindawi.com/journals/omcl/2021/9264639/
6. Peake JM, Neubauer O, Della Gatta PA, Nosaka K. Muscle damage and inflammation during recovery from exercise. J Appl Physiol. marzo de 2017;122(3):559-70.
7. Campbell MS, Carlini NA, Fleenor BS. Influence of curcumin on performance and post-exercise recovery. Crit Rev Food Sci Nutr. 2021;61(7):1152-62.
8. Rawson ES, Miles MP, Larson-Meyer DE. Dietary Supplements for Health, Adaptation, and Recovery in Athletes. Int J Sport Nutr Exerc Metab. 1 de marzo de 2018;28(2):188-99.
9. Nanavati K, Rutherfurd-Markwick K, Lee SJ, Bishop NC, Ali A. Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review. Eur J Nutr. 1 de diciembre de 2022;61(8):3835-55.
10. Nicol LM, Rowlands DS, Fazakerly R, Kellett J. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). Eur J Appl Physiol. 1 de agosto de 2015;115(8):1769-77.
11. Tsuruta A, Horiike T, Yoshimura M, Nagaoka I. Evaluation of the effect of the administration of a glucosamine‑containing supplement on biomarkers for cartilage metabolism in soccer players: A randomized double‑blind placebo‑controlled study. Mol Med Rep. 1 de octubre de 2018;18(4):3941-8.
12. Martel-Pelletier J, Boileau C, Pelletier JP, Roughley PJ. Cartilage in normal and osteoarthritis conditions. Best Pract Res Clin Rheumatol. 1 de abril de 2008;22(2):351-84.
13. O’Kane JW, Hutchinson E, Atley LM, Eyre DR. Sport-related differences in biomarkers of bone resorption and cartilage degradation in endurance athletes. Osteoarthritis Cartilage. 1 de enero de 2006;14(1):71-6.
14. Jorge PB, Sprey JWC, Runco GM, Lima MV de, Severino NR, Santili C. Difference in Articular Degeneration Depending on the Type of Sport. Rev Bras Ortop. septiembre de 2019;54(5):509-15.
15. Clark KL, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 1 de mayo de 2008;24(5):1485-96.
16. Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl Physiol Nutr Metab. junio de 2017;42(6):588-95.
17. Di Cesare Mannelli L, Micheli L, Zanardelli M, Ghelardini C. Low dose native type II collagen prevents pain in a rat osteoarthritis model. BMC Musculoskelet Disord. 1 de agosto de 2013;14:228.
18. Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. junio de 2016;48(2):95-101.
19. Serhan CN, Levy BD. Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators [Internet]. American Society for Clinical Investigation; 2018 [citado 21 de noviembre de 2022]. Disponible en: https://www.jci.org/articles/view/97943/pdf
20. Corder KE, Newsham KR, McDaniel JL, Ezekiel UR, Weiss EP. Effects of Short-Term Docosahexaenoic Acid Supplementation on Markers of Inflammation after Eccentric Strength Exercise in Women. J Sports Sci Med. marzo de 2016;15(1):176-83.
21. Jouris KB, McDaniel JL, Weiss EP. The Effect of Omega-3 Fatty Acid Supplementation on the Inflammatory Response to eccentric strength exercise. J Sports Sci Med. 2011;10(3):432-8.
22. Walsh NP. Nutrition and Athlete Immune Health: New Perspectives on an Old Paradigm. Sports Med. diciembre de 2019;49(S2):153-68.
23. Zoppi CC, Hohl R, Silva FC, Lazarim FL, Neto JA, Stancanneli M, et al. Vitamin C and E Supplementation Effects in Professional Soccer Players Under Regular Training. J Int Soc Sports Nutr. 1 de diciembre de 2006;3(2):37.
24. Heaton LE, Davis JK, Rawson ES, Nuccio RP, Witard OC, Stein KW, et al. Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview. Sports Med. noviembre de 2017;47(11):2201-18.
25. Li G, Cheng T, Yu X. The Impact of Trace Elements on Osteoarthritis. Front Med [Internet]. 2021 [citado 21 de noviembre de 2022];8. Disponible en: https://www.frontiersin.org/articles/10.3389/fmed.2021.771297
26. Das A, Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. septiembre de 2000;8(5):343-50.
27. Wei M, Huang Q, Dai Y, Zhou H, Cui Y, Song W, et al. Manganese, iron, copper, and selenium co-exposure and osteoporosis risk in Chinese adults. J Trace Elem Med Biol Organ Soc Miner Trace Elem GMS. julio de 2022;72:126989.
28. Lin R, Deng C, Li X, Liu Y, Zhang M, Qin C, et al. Copper-incorporated bioactive glass-ceramics inducing anti-inflammatory phenotype and regeneration of cartilage/bone interface. Theranostics. 2019;9(21):6300-13.
29. Barreca D, Gattuso G, Bellocco E, Calderaro A, Trombetta D, Smeriglio A, et al. Flavanones: Citrus phytochemical with health-promoting properties. Biofactors. 2017;43(4):495-506.
30. Mas-Capdevila A, Teichenne J, Domenech-Coca C, Caimari A, Del Bas JM, Escoté X, et al. Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability. Nutrients. 2020;12(5):1488.
31. Xiong H, Wang J, Ran Q, Lou G, Peng C, Gan Q, et al. Hesperidin: A Therapeutic Agent For Obesity. Drug Devel Ther. 2019;13:3855-66.
32. Tejada S, Pinya S, Martorell M, Capó X, Tur JA, Pons A, et al. Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus. Curr Med Chem. 2018;25(37):4929-45.
33. Hajialyani M, Hosein Farzaei M, Echeverría J, Nabavi SM, Uriarte E, Sobarzo-Sánchez E. Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence. Molecules. 2019;24(3).
34. Li C, Schluesener H. Health-promoting effects of the citrus flavanone hesperidin. Crit Rev Food Sci Nutr. 2017;57(3):613-31.
35. Li Y, Kandhare AD, Mukherjee AA, Bodhankar SL. Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats. Regul Toxicol Pharmacol. 2019;105:77-85.
36. Estruel-Amades S, Massot-Cladera M, Pérez-Cano FJ, Franch À, Castell M, Camps-Bossacoma M. Hesperidin Effects on Gut Microbiota and Gut-Associated Lymphoid Tissue in Healthy Rats. Nutrients. 2019;11(2).
37. Camps-Bossacoma M, Franch À, Pérez-Cano FJ, Castell M. Influence of Hesperidin on the Systemic and Intestinal Rat Immune Response. Nutrients. 2017;9(6).
38. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Phytother Res. 2017;31(10):1539-45.
39. Crimaldi S, Liguori S, Tamburrino P, Moretti A, Paoletta M, Toro G, et al. The Role of Hyaluronic Acid in Sport-Related Tendinopathies: A Narrative Review. Medicina (Mex). 12 de octubre de 2021;57(10):1088.
40. Oe M, Tashiro T, Yoshida H, Nishiyama H, Masuda Y, Maruyama K, et al. Oral hyaluronan relieves knee pain: a review. Nutr J. 27 de enero de 2016;15:11.
41. Moskowitz RW. Hyaluronic acid supplementation. Curr Rheumatol Rep. diciembre de 2000;2(6):466-71.
42. Wang SJ, Wang YH, Huang LC. The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial. Medicine (Baltimore). 5 de febrero de 2021;100(5):e24252.
Articulations
Supplement that helps the maintenance of bones and joints.
- Unit price
- /per
Are you experiencing discomfort in your joints?
NDL Pro-Health Articulations is a dietary supplement formulated from nutrients such as type II collagen, hyaluronic acid, turmeric longa extract, manganese, copper, vitamin C and Lipinova R with a high content of Omega 3 fatty acids.
Free shipping to mainland Spain for orders over 24.95 €
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Adding product to your cart
NDL Pro-Health Articulations is a dietary supplement formulated from nutrients such as manganese, which contributes to maintaining healthy bones under normal conditions, and copper, which contributes to the maintenance of connective tissue under normal conditions Vitamin C contributes to the normal formation of collagen for the normal functioning of bones and the normal functioning of cartilage.
Turmeric Longa, Type II Collagen, Hyaluronic Acid and Lipinova- 11TG R with high content of Omega 3 fatty acids.
Contains Hesperidin*, a flavonoid present in high concentrations in citrus fruits, with antioxidant and anti-inflammatory properties.
Certain physical activity along with getting older have their effects on articulations, tendons and ligaments. NDL Pro-Health Articulations combines the properties of the highest quality ingredients in an easy-to-take dietary supplement to allow you to access all its benefits.
Its formula is fortified with specific ingredients:
Collagen is very important for the elasticity of various tissues, where it plays a fundamental structural role.
Curcuma Longa has a preventive effect on oxidative damage.
Lipinova-11TG R is a unique ingredient obtained from fish oils that supports the body's own ability to resolve inflammation.
Hyaluronic acid is found naturally in many tissues and fluids but is most abundant in articular cartilage and synovium.
Synovium is a liquid that fills the joint cavities with its presence and is characterized by the presence of high concentrations of hyaluronic acid, glycoproteins and ions.
All NDL Pro-Health products meet the strictest quality criteria.
Take one capsule per day. Take with a glass of water.
INGREDIENTS |
MG/CAP |
FUNCTIONALITY |
VNR |
Turmeric Extract |
100 |
Anti-inflammatory and antioxidant |
* |
Collagen type II |
40 |
Joint recovery |
* |
Lipinova – 11TG |
40 |
Joint and muscle recovery |
* |
Vitamin C |
40 |
Reduces tiredness and fatigue |
50% |
Manganese sulphate |
0.923 |
Bone maintenance |
15% |
Copper sulphate |
0.419 |
Anti-inflammatory |
17% |
Hesperidin |
50 |
Antioxidant and anti-inflammatory |
* |
Hyaluronic acid |
33.33 |
Joint recovery |
* |
NDL PRO HEALTH Articulations do not contain any substances included in the WADA prohibited list either in their composition or in the manufacturing process.
95% TURMERIC: Intense physical exercise, especially high intensity exercise with a high number of eccentric contractions, leads to muscle damage (EIMD, “exercise-induced muscle damage”) and the subsequent development of muscle numbness (DOMS, “Delayed Onset Muscle Soreness Muscle damage induces an inflammatory response associated with a loss in muscle strength, loss of mobility, swelling, numbness, and an increase in the amount of muscle proteins in the blood (such as creatine kinase, CK). This is followed by an inflammatory cascade trigger where pro-inflammatory cytokines increase, the accumulation of advanced glycosylation end products (AGEs) and reactive oxygen species (ROS) occurs (5). Although this is part of recovery and the natural response to exercise, it can cause fatigue and decreased athletic performance (6). Addressing these problems may be especially important in sports where muscle soreness could hinder performance in subsequent routines (for example, sports competitions extended over time).
Curcumin (a natural polyphenol and the main constituent of the spice turmeric) has recently attracted the focus of various studies focused on recovery after exercise (7–9) thanks to its anti-inflammatory and antioxidant benefits. These studies show improvement in the measures of pain and sensitivity (discomfort) perceived by the athletes themselves, evidencing a reduction in muscle damage and decreasing markers of inflammation, increasing antioxidant capacity, decreasing markers of oxidative stress, AGEs. and reducing DOMs (5, 7, 9, 10).
TYPE II COLLAGEN Excessive mobility, as well as repeated loading on joints, generate damage that comes mainly from the degradation of cartilage, of which collagen is the main component(11). Type II collagen is a major component of cartilage (12). During intense exercise routines, the collagen in the joints degrades, which affects the physical properties of the joints, leading to inflammation and subsequent pain. The released collagen fragments also encourage the immune system to recognise the body's own collagen as a potentially harmful component and actively attack it.
This feeds back into the cycle of collagen destruction, increasing inflammation and joint pain as well as being directly related to the high incidence of osteoarthritis and other autoimmune diseases in athletes (13). Within this context, a chronic source of hydrolysed collagen in nutritional supplements has been shown to be highly beneficial for joint care, benefiting the replacement of degraded collagen during exercise routines(14–16). In any case, the immune response activated during the collagen degradation processes associated with exercise continues to represent a threat to athletes. This is the reason behind Cantabria Labs recommendation of a strategy that protects the collagen of the joints instead of replacing it once it has already been degraded. This involves the addition of a source of natural collagen specifically in its native form (B-2Cool).
When ingested, this type of collagen reduces autoimmune reactions against its own collagen (induction of oral tolerance), reducing its destruction. This mechanism of action has shown very promising results in preclinical and clinical trials, while also reducing different parameters associated with pain (17, 18).
Therefore, not only would joint pain be actively treated, but it would also ensure the long-term health of athletes protecting their joints.
DIFFERENCE TYPE I COLLAGEN AND TYPE II COLLAGEN
- Type I collagen: This type of collagen is the most abundant in the human body and is found in the skin, bones, tendons, ligaments and other connective tissues. It provides strength and support to these tissues and is important for the elasticity and strength of the skin.
- Type II Collagen: This type of collagen is found in cartilage, which is a connective tissue that helps cushion joints and bones Type II Collagen provides strength and elasticity to cartilage and is important for its ability to absorb shock and support the weight of the body.
To sum up, the main difference between type I and type II collagen is their location in the body and their function.
While type I collagen is important for the strength and elasticity of skin, bones and connective tissues, type II collagen is essential for the health and function of cartilage, which cushions joints and bones.
LIPINOVA-11TG – SPMs (ProResolve SPMs): Exhaustive training leads to muscle damage and inflammation that should be resolved correctly as part of the natural recovery process from intense exercise (6). If this does not occur, chronic inflammation, the continued production of ROS, the appearance of fatigue, pain, and the early development of autoimmune diseases such as different types of arthritis in the long term occur. The so-called pro-resolving mediators (SPMs) intervene in the correct resolution of inflammation (19). This formula incorporates a mixture of omega-3 polyunsaturated fatty acids (including EPA -eicosapentaenoic acid- and DHA -docosahexaenoic acid-), necessary for the synthesis of SPMs and whose effectiveness in the form of supplements has been demonstrated in clinical studies (20, 21).
100% VITAMIN C: Playing a mainly antioxidant role, it also promotes collagen synthesis, iron absorption (counteracting athlete's anaemia), helps control ROS levels, inflammation and reduce tiredness and fatigue (4, 22–24).
MANGANESE: Protects joint wear and tear, due to being essential for cartilage repair (25, 26) and bone maintenance, improving bone density (27).
COPPER: Copper at low concentrations improves joints, acting at the level of both cartilage and bone. It facilitates the regeneration of chondrocytes, reduces inflammation and the likelihood of osteoarthritis (25, 28).
HESPERIDIN: Flavonoids are bioactive substances found mainly in fruits and vegetables, with more than 15,000 molecules identified within this family (29). One of the best-known flavonoids is hesperidin, which is present in high concentrations in citrus fruits. When hesperidin reaches the intestine, the bacterial flora converts it into hesperetin, which is the main metabolite of hesperidin (30). Previous studies have shown that hesperidin has various pharmacological activities such as anti-atherogenic, antihyperlipidemic, antidiabetic, venotonic, cardioprotective, anti-inflammatory and antihypertensive (neurological, cardiovascular, insulin-sensitizing) activities due to its antioxidant and anti-inflammatory properties. Hesperidin inhibits the secretion of pro-inflammatory cytokines such as TNFα, IL-6, IFN-γ and IL-2 (31–34). The intake of hesperidin has also been demonstrated to be extremely safe (35), modulating leukocyte gene expression, enhancing its antioxidant and inflammatory profile (36–38).
HYALURONIC ACID: A component of the synovial fluid of the joint, the extracellular matrix of cartilage and tendons (39), taking it orally in supplement form would function in a similar way as described by collagen in its native state, actively reducing joint pain and preventing the appearance of autoimmune arthritis (40–42)
NDL PRO HEALTH Articulations do not contain any substances included in the WADA prohibited list in either their composition or during their manufacturing process.
Do not exceed the expressly recommended daily dose. Nutritional supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle It should not be used by pregnant or lactating women or anyone under 18 years of age. Keep out of the reach of children. Store in a cool, dry place away from light and heat sources. The indicated expiry date refers to the product stored correctly in its original packaging.
1. Feeley BT, Kennelly S, Barnes RP, Muller MS, Kelly BT, Rodeo SA, et al. Epidemiology of National Football League Training Camp Injuries from 1998 to 2007. Am J Sports Med. 1 de agosto de 2008;36(8):1597-603.
2. Hootman JM, Dick R, Agel J. Epidemiology of Collegiate Injuries for 15 Sports: Summary and Recommendations for Injury Prevention Initiatives. J Athl Train. 2007;42(2):311-9.
3. Hawkins RD, Hulse MA, Wilkinson C, Hodson A, Gibson M. The association football medical research programme: an audit of injuries in professional football. Br J Sports Med. 1 de febrero de 2001;35(1):43-7.
4. Shaw G, Lee-Barthel A, Ross ML, Wang B, Baar K. Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis. Am J Clin Nutr. 1 de enero de 2017;105(1):136-43.
5. Effects of Curcumin Supplementation on Inflammatory Markers, Muscle Damage, and Sports Performance during Acute Physical Exercise in Sedentary Individuals [Internet]. [citado 31 de octubre de 2022]. Disponible en: https://www.hindawi.com/journals/omcl/2021/9264639/
6. Peake JM, Neubauer O, Della Gatta PA, Nosaka K. Muscle damage and inflammation during recovery from exercise. J Appl Physiol. marzo de 2017;122(3):559-70.
7. Campbell MS, Carlini NA, Fleenor BS. Influence of curcumin on performance and post-exercise recovery. Crit Rev Food Sci Nutr. 2021;61(7):1152-62.
8. Rawson ES, Miles MP, Larson-Meyer DE. Dietary Supplements for Health, Adaptation, and Recovery in Athletes. Int J Sport Nutr Exerc Metab. 1 de marzo de 2018;28(2):188-99.
9. Nanavati K, Rutherfurd-Markwick K, Lee SJ, Bishop NC, Ali A. Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review. Eur J Nutr. 1 de diciembre de 2022;61(8):3835-55.
10. Nicol LM, Rowlands DS, Fazakerly R, Kellett J. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). Eur J Appl Physiol. 1 de agosto de 2015;115(8):1769-77.
11. Tsuruta A, Horiike T, Yoshimura M, Nagaoka I. Evaluation of the effect of the administration of a glucosamine‑containing supplement on biomarkers for cartilage metabolism in soccer players: A randomized double‑blind placebo‑controlled study. Mol Med Rep. 1 de octubre de 2018;18(4):3941-8.
12. Martel-Pelletier J, Boileau C, Pelletier JP, Roughley PJ. Cartilage in normal and osteoarthritis conditions. Best Pract Res Clin Rheumatol. 1 de abril de 2008;22(2):351-84.
13. O’Kane JW, Hutchinson E, Atley LM, Eyre DR. Sport-related differences in biomarkers of bone resorption and cartilage degradation in endurance athletes. Osteoarthritis Cartilage. 1 de enero de 2006;14(1):71-6.
14. Jorge PB, Sprey JWC, Runco GM, Lima MV de, Severino NR, Santili C. Difference in Articular Degeneration Depending on the Type of Sport. Rev Bras Ortop. septiembre de 2019;54(5):509-15.
15. Clark KL, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 1 de mayo de 2008;24(5):1485-96.
16. Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl Physiol Nutr Metab. junio de 2017;42(6):588-95.
17. Di Cesare Mannelli L, Micheli L, Zanardelli M, Ghelardini C. Low dose native type II collagen prevents pain in a rat osteoarthritis model. BMC Musculoskelet Disord. 1 de agosto de 2013;14:228.
18. Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. junio de 2016;48(2):95-101.
19. Serhan CN, Levy BD. Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators [Internet]. American Society for Clinical Investigation; 2018 [citado 21 de noviembre de 2022]. Disponible en: https://www.jci.org/articles/view/97943/pdf
20. Corder KE, Newsham KR, McDaniel JL, Ezekiel UR, Weiss EP. Effects of Short-Term Docosahexaenoic Acid Supplementation on Markers of Inflammation after Eccentric Strength Exercise in Women. J Sports Sci Med. marzo de 2016;15(1):176-83.
21. Jouris KB, McDaniel JL, Weiss EP. The Effect of Omega-3 Fatty Acid Supplementation on the Inflammatory Response to eccentric strength exercise. J Sports Sci Med. 2011;10(3):432-8.
22. Walsh NP. Nutrition and Athlete Immune Health: New Perspectives on an Old Paradigm. Sports Med. diciembre de 2019;49(S2):153-68.
23. Zoppi CC, Hohl R, Silva FC, Lazarim FL, Neto JA, Stancanneli M, et al. Vitamin C and E Supplementation Effects in Professional Soccer Players Under Regular Training. J Int Soc Sports Nutr. 1 de diciembre de 2006;3(2):37.
24. Heaton LE, Davis JK, Rawson ES, Nuccio RP, Witard OC, Stein KW, et al. Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview. Sports Med. noviembre de 2017;47(11):2201-18.
25. Li G, Cheng T, Yu X. The Impact of Trace Elements on Osteoarthritis. Front Med [Internet]. 2021 [citado 21 de noviembre de 2022];8. Disponible en: https://www.frontiersin.org/articles/10.3389/fmed.2021.771297
26. Das A, Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. septiembre de 2000;8(5):343-50.
27. Wei M, Huang Q, Dai Y, Zhou H, Cui Y, Song W, et al. Manganese, iron, copper, and selenium co-exposure and osteoporosis risk in Chinese adults. J Trace Elem Med Biol Organ Soc Miner Trace Elem GMS. julio de 2022;72:126989.
28. Lin R, Deng C, Li X, Liu Y, Zhang M, Qin C, et al. Copper-incorporated bioactive glass-ceramics inducing anti-inflammatory phenotype and regeneration of cartilage/bone interface. Theranostics. 2019;9(21):6300-13.
29. Barreca D, Gattuso G, Bellocco E, Calderaro A, Trombetta D, Smeriglio A, et al. Flavanones: Citrus phytochemical with health-promoting properties. Biofactors. 2017;43(4):495-506.
30. Mas-Capdevila A, Teichenne J, Domenech-Coca C, Caimari A, Del Bas JM, Escoté X, et al. Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability. Nutrients. 2020;12(5):1488.
31. Xiong H, Wang J, Ran Q, Lou G, Peng C, Gan Q, et al. Hesperidin: A Therapeutic Agent For Obesity. Drug Devel Ther. 2019;13:3855-66.
32. Tejada S, Pinya S, Martorell M, Capó X, Tur JA, Pons A, et al. Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus. Curr Med Chem. 2018;25(37):4929-45.
33. Hajialyani M, Hosein Farzaei M, Echeverría J, Nabavi SM, Uriarte E, Sobarzo-Sánchez E. Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence. Molecules. 2019;24(3).
34. Li C, Schluesener H. Health-promoting effects of the citrus flavanone hesperidin. Crit Rev Food Sci Nutr. 2017;57(3):613-31.
35. Li Y, Kandhare AD, Mukherjee AA, Bodhankar SL. Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats. Regul Toxicol Pharmacol. 2019;105:77-85.
36. Estruel-Amades S, Massot-Cladera M, Pérez-Cano FJ, Franch À, Castell M, Camps-Bossacoma M. Hesperidin Effects on Gut Microbiota and Gut-Associated Lymphoid Tissue in Healthy Rats. Nutrients. 2019;11(2).
37. Camps-Bossacoma M, Franch À, Pérez-Cano FJ, Castell M. Influence of Hesperidin on the Systemic and Intestinal Rat Immune Response. Nutrients. 2017;9(6).
38. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2 Diabetes: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Phytother Res. 2017;31(10):1539-45.
39. Crimaldi S, Liguori S, Tamburrino P, Moretti A, Paoletta M, Toro G, et al. The Role of Hyaluronic Acid in Sport-Related Tendinopathies: A Narrative Review. Medicina (Mex). 12 de octubre de 2021;57(10):1088.
40. Oe M, Tashiro T, Yoshida H, Nishiyama H, Masuda Y, Maruyama K, et al. Oral hyaluronan relieves knee pain: a review. Nutr J. 27 de enero de 2016;15:11.
41. Moskowitz RW. Hyaluronic acid supplementation. Curr Rheumatol Rep. diciembre de 2000;2(6):466-71.
42. Wang SJ, Wang YH, Huang LC. The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial. Medicine (Baltimore). 5 de febrero de 2021;100(5):e24252.
Compre el producto por recomendación y la verdad es que me esta yendo bastante bien y noto la mejoría en mi rodilla maltrecha. Lo puedo recomendar sin duda alguna.
Poco más que decir, bueno si: G R A C I A S
Ma tendinite a disparu, mon arthrose au genou ne me fait plus souffrir.
Hilft wirklich bei meinen Arthroseproblemen.
Funciona muy bien
Lo acabo de comprar y llevo solo dos semanas tomando este colágeno, así que no puedo dar una valoración. Lo compré por los componentes que tiene. Espero notar resultados. Me regalaron unas vitaminas. Muchas gracias
Combine with