Do you feel low on energy even after resting? Keep reading because we’re bringing you the best vitamins for fatigue, which is often a sign that something in your body needs attention.
While the causes can vary—from stress and lack of sleep to an unbalanced diet—one of the most common reasons behind fatigue is a deficiency in certain essential vitamins.
Besides being important for staying healthy, vitamins also play a key role in energy production, proper nervous system function, and the body’s response to stress. When there's a deficiency, your body feels it... and fatigue kicks in.
In this article, we’ll explain which are the best vitamins for physical and mental fatigue, how they work in your body, and when it might be useful to incorporate them into your routine to restore energy and well-being.
What role do vitamins play in energy and fatigue?
Vitamins are essential micronutrients involved in numerous biological processes, and one of the most important is energy production. Although they don’t provide calories themselves, many vitamins act as cofactors in the chemical reactions that convert food into fuel for the body.
When there’s a deficiency in certain vitamins, this process becomes less efficient, which can result in constant fatigue, difficulty concentrating, and even low mood.
Moreover, some vitamins have a direct impact on the nervous system and stress regulation, two factors closely linked to both physical and mental fatigue.
That’s why maintaining adequate vitamin levels is essential to feeling energized, focused, and ready to face the day.
The best vitamins to fight fatigue
We know that finding the best vitamin for fatigue can be challenging, as it depends on each person’s needs.
Below, we highlight the top vitamins that can help reduce fatigue, along with their main benefits and when you should pay extra attention to them:
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Vitamin B12 (Cobalamin):
- Involved in red blood cell formation and energy metabolism.
- Essential for proper nervous system function.
- Deficiency can lead to extreme fatigue, muscle weakness, and difficulty concentrating.
- Natural sources: meat, fish, eggs, dairy. Supplementation is recommended for vegans or people with absorption issues.
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Vitamin B Complex (B1, B2, B3, B5, B6, B7, and B9):
- All B vitamins support cellular metabolism and energy production from food.
- Especially helpful during periods of stress, mental fatigue, or physical overload.
- A balanced combination of these vitamins can improve mood, mental clarity, and overall vitality.
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Vitamin C (Ascorbic Acid):
- Strengthens the immune system and protects cells from oxidative damage.
- Helps reduce fatigue and enhances iron absorption, another key nutrient against tiredness.
- Found in citrus fruits, kiwi, strawberries, bell peppers, and leafy greens.
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Vitamin D:
- Crucial for bone and muscle health, as well as immune balance and mood regulation.
- Deficiency is associated with chronic fatigue, especially in people with low sun exposure.
- If you experience persistent fatigue without a clear cause, it’s recommended to check your vitamin D levels.
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Iron (not a vitamin, but crucial in this context):
- Essential for transporting oxygen in the blood via hemoglobin.
- Iron deficiency can cause anemia, one of the most common causes of severe fatigue.
- It’s important to pair it with vitamin C to improve absorption.
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Magnesium (optional, but relevant):
- Involved in over 300 biochemical reactions, many of them related to energy and the nervous system.
- Helps reduce fatigue, improves sleep quality, and supports proper muscle function.
In short, maintaining adequate levels of these vitamins is key to fighting fatigue and restoring both physical and mental energy. A balanced diet is the first step, but in some cases, supplements can make a real difference in helping you feel active and revitalized again.
When to consider a multivitamin supplement
Although it’s ideal to get your vitamins through a varied and balanced diet, there are situations where supplementation may be helpful or even necessary. Examples include:
- Insufficient or restrictive diets: very low-calorie, vegetarian, or vegan diets may not meet all vitamin requirements, especially B vitamins and B12.
- High physical or mental demands: athletes, people with intense workdays, or during periods of high stress may benefit from extra nutritional support.
- Persistent fatigue without a clear cause: if tiredness persists despite good sleep and a proper diet, it might be worth checking your vitamin levels with a blood test.
- Seasonal changes or recovery periods: fall, winter, or convalescence periods can lower energy levels, and a multivitamin may help restore balance.
Still, to find the best vitamin for fatigue, it’s important to choose a high-quality supplement, with balanced formulas, good bioavailability, and ideally consult a healthcare professional before starting any new regimen.
Tips for combating fatigue holistically
While vitamins can be powerful allies, fatigue isn’t always solved by supplements alone. To restore and maintain energy over the long term, it’s essential to adopt a holistic approach that includes healthy habits in different areas:
Balanced diet: a diet rich in fruits, vegetables, quality proteins, healthy fats, and whole grains is essential to meet the nutritional needs that affect your vitality.
Restful sleep: sleeping 7 to 9 hours a night allows the body to regenerate and recharge energy. Sleep hygiene is as important as the number of hours.
Proper hydration: even mild dehydration can cause mental and physical fatigue. Make sure to drink enough water throughout the day.
Regular physical activity: moderate exercise improves circulation, stimulates metabolism, and helps fight chronic fatigue. It also promotes deeper, more restorative sleep.
Stress management: chronic stress drains both physical and mental resources. Techniques like meditation, deep breathing, or simply disconnecting can help recharge emotional energy.
In conclusion, fatigue can have many causes, but one of the most common—and often underestimated—is a lack of essential vitamins. Nutrients like B12, the B-complex, vitamin C, D, or iron are key to maintaining energy levels, mental performance, and overall well-being.
If you feel tired every day, reviewing your habits, diet, and considering the help of supplements can be the first step to getting your energy back. Remember that no supplement can replace a healthy lifestyle, but in many cases, the best vitamins for fatigue can be the boost your body needs to get back to 100%.

From the NDL Pro-Health team we will provide you with tips to maintain a healthy lifestyle. Sharing knowledge and product recommendations to offer optimal solutions for your daily routine, for your workouts and subsequent recovery, all with the goal of helping you achieve physical and mental wellness.