NDL Pro-Health Articulations is a dietary supplement formulated from nutrients such as manganese, which contributes to maintaining healthy bones under normal conditions, and copper, which contributes to the maintenance of connective tissue under normal conditions Vitamin C contributes to the normal formation of collagen for the normal functioning of bones and the normal functioning of cartilage.

Turmeric Longa, Type II Collagen, Hyaluronic Acid and Lipinova- 11TG R with high content of Omega 3 fatty acids.

Contains Hesperidin*, a flavonoid present in high concentrations in citrus fruits, with antioxidant and anti-inflammatory properties.

Certain physical activity along with getting older have their effects on articulations, tendons and ligaments. NDL Pro-Health Articulations combines the properties of the highest quality ingredients in an easy-to-take dietary supplement to allow you to access all its benefits.

Its formula is fortified with specific ingredients:

Collagen is very important for the elasticity of various tissues, where it plays a fundamental structural role.

Curcuma Longa has a preventive effect on oxidative damage.

Lipinova-11TG R is a unique ingredient obtained from fish oils that supports the body's own ability to resolve inflammation.

Hyaluronic acid is found naturally in many tissues and fluids but is most abundant in articular cartilage and synovium.

Synovium is a liquid that fills the joint cavities with its presence and is characterized by the presence of high concentrations of hyaluronic acid, glycoproteins and ions.

All NDL Pro-Health products meet the strictest quality criteria.

Take one capsule per day. Take with a glass of water.

95% TURMERIC: Intense physical exercise, especially high intensity exercise with a high number of eccentric contractions, leads to muscle damage (EIMD, “exercise-induced muscle damage”) and the subsequent development of muscle numbness (DOMS, “Delayed Onset Muscle Soreness Muscle damage induces an inflammatory response associated with a loss in muscle strength, loss of mobility, swelling, numbness, and an increase in the amount of muscle proteins in the blood (such as creatine kinase, CK). This is followed by an inflammatory cascade trigger where pro-inflammatory cytokines increase, the accumulation of advanced glycosylation end products (AGEs) and reactive oxygen species (ROS) occurs (5). Although this is part of recovery and the natural response to exercise, it can cause fatigue and decreased athletic performance (6). Addressing these problems may be especially important in sports where muscle soreness could hinder performance in subsequent routines (for example, sports competitions extended over time).

Curcumin (a natural polyphenol and the main constituent of the spice turmeric) has recently attracted the focus of various studies focused on recovery after exercise (7–9) thanks to its anti-inflammatory and antioxidant benefits. These studies show improvement in the measures of pain and sensitivity (discomfort) perceived by the athletes themselves, evidencing a reduction in muscle damage and decreasing markers of inflammation, increasing antioxidant capacity, decreasing markers of oxidative stress, AGEs. and reducing DOMs (5, 7, 9, 10).

TYPE II COLLAGEN Excessive mobility, as well as repeated loading on joints, generate damage that comes mainly from the degradation of cartilage, of which collagen is the main component(11). Type II collagen is a major component of cartilage (12). During intense exercise routines, the collagen in the joints degrades, which affects the physical properties of the joints, leading to inflammation and subsequent pain. The released collagen fragments also encourage the immune system to recognise the body's own collagen as a potentially harmful component and actively attack it.
 This feeds back into the cycle of collagen destruction, increasing inflammation and joint pain as well as being directly related to the high incidence of osteoarthritis and other autoimmune diseases in athletes (13). Within this context, a chronic source of hydrolysed collagen in nutritional supplements has been shown to be highly beneficial for joint care, benefiting the replacement of degraded collagen during exercise routines(14–16). In any case, the immune response activated during the collagen degradation processes associated with exercise continues to represent a threat to athletes. This is the reason behind Cantabria Labs recommendation of a strategy that protects the collagen of the joints instead of replacing it once it has already been degraded. This involves the addition of a source of natural collagen specifically in its native form (B-2Cool).
 When ingested, this type of collagen reduces autoimmune reactions against its own collagen (induction of oral tolerance), reducing its destruction. This mechanism of action has shown very promising results in preclinical and clinical trials, while also reducing different parameters associated with pain (17, 18).
 Therefore, not only would joint pain be actively treated, but it would also ensure the long-term health of athletes protecting their joints.

DIFFERENCE TYPE I COLLAGEN AND TYPE II COLLAGEN

1. Type I collagen: This type of collagen is the most abundant in the human body and is found in the skin, bones, tendons, ligaments and other connective tissues. It provides strength and support to these tissues and is important for the elasticity and strength of the skin.
2. Type II Collagen: This type of collagen is found in cartilage, which is a connective tissue that helps cushion joints and bones Type II Collagen provides strength and elasticity to cartilage and is important for its ability to absorb shock and support the weight of the body.

To sum up, the main difference between type I and type II collagen is their location in the body and their function.

While type I collagen is important for the strength and elasticity of skin, bones and connective tissues, type II collagen is essential for the health and function of cartilage, which cushions joints and bones.

LIPINOVA-11TG – SPMs (ProResolve SPMs): Exhaustive training leads to muscle damage and inflammation that should be resolved correctly as part of the natural recovery process from intense exercise (6). If this does not occur, chronic inflammation, the continued production of ROS, the appearance of fatigue, pain, and the early development of autoimmune diseases such as different types of arthritis in the long term occur. The so-called pro-resolving mediators (SPMs) intervene in the correct resolution of inflammation (19). This formula incorporates a mixture of omega-3 polyunsaturated fatty acids (including EPA -eicosapentaenoic acid- and DHA -docosahexaenoic acid-), necessary for the synthesis of SPMs and whose effectiveness in the form of supplements has been demonstrated in clinical studies (20, 21).

100% VITAMIN C: Playing a mainly antioxidant role, it also promotes collagen synthesis, iron absorption (counteracting athlete's anaemia), helps control ROS levels, inflammation and reduce tiredness and fatigue (4, 22–24). 

MANGANESE: Protects joint wear and tear, due to being essential for cartilage repair (25, 26) and bone maintenance, improving bone density (27).

COPPER: Copper at low concentrations improves joints, acting at the level of both cartilage and bone. It facilitates the regeneration of chondrocytes, reduces inflammation and the likelihood of osteoarthritis (25, 28).

HESPERIDIN: Flavonoids are bioactive substances found mainly in fruits and vegetables, with more than 15,000 molecules identified within this family (29). One of the best-known flavonoids is hesperidin, which is present in high concentrations in citrus fruits. When hesperidin reaches the intestine, the bacterial flora converts it into hesperetin, which is the main metabolite of hesperidin (30). Previous studies have shown that hesperidin has various pharmacological activities such as anti-atherogenic, antihyperlipidemic, antidiabetic, venotonic, cardioprotective, anti-inflammatory and antihypertensive (neurological, cardiovascular, insulin-sensitizing) activities due to its antioxidant and anti-inflammatory properties. Hesperidin inhibits the secretion of pro-inflammatory cytokines such as TNFα, IL-6, IFN-γ and IL-2 (31–34). The intake of hesperidin has also been demonstrated to be extremely safe (35), modulating leukocyte gene expression, enhancing its antioxidant and inflammatory profile (36–38).

HYALURONIC ACID: A component of the synovial fluid of the joint, the extracellular matrix of cartilage and tendons (39), taking it orally in supplement form would function in a similar way as described by collagen in its native state, actively reducing joint pain and preventing the appearance of autoimmune arthritis (40–42)

NDL PRO HEALTH Articulations do not contain any substances included in the WADA prohibited list in either their composition or during their manufacturing process.

Do not exceed the expressly recommended daily dose. Nutritional supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle It should not be used by pregnant or lactating women or anyone under 18 years of age. Keep out of the reach of children. Store in a cool, dry place away from light and heat sources. The indicated expiry date refers to the product stored correctly in its original packaging.

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2 Hootman JM, Dick R, Agel J. Epidemiologie von College-Verletzungen bei 15 Sportarten: Zusammenfassung und Empfehlungen für Initiativen zur Verletzungsprävention. J Athl Train. 2007;42(2):311-9.  

3 Hawkins RD, Hulse MA, Wilkinson C, Hodson A, Gibson M. The association football medical research programme: an audit of injuries in professional football. Br J Sports Med. 1. Februar 2001;35(1):43-7.  

4 Shaw G, Lee-Barthel A, Ross ML, Wang B, Baar K. Vitamin C-angereicherte Gelatine vor intermittierender Aktivität steigert die Kollagensynthese. Am J Clin Nutr. January 1, 2017;105(1):136-43.  

5 Auswirkungen einer Curcumin-Supplementierung auf Entzündungsmarker, Muskelschäden und die sportliche Leistung bei akuter körperlicher Anstrengung bei sitzenden Personen [Internet]. [zitiert am 31. Oktober 2022]. Verfügbar unter: https://www.hindawi.com/journals/omcl/2021/9264639/

6. Peake JM, Neubauer O, Della Gatta PA, Nosaka K. Muskelschäden und Entzündungen während der Erholung nach dem Training. J Appl Physiol. March 2017;122(3):559-70.  

7 Campbell MS, Carlini NA, Fleenor BS. Einfluss von Curcumin auf die Leistung und die Erholung nach dem Training. Crit Rev Food Sci Nutr. 2021;61(7):1152-62.  

8 Rawson ES, Miles MP, Larson-Meyer DE. Nahrungsergänzungsmittel für Gesundheit, Adaptation und Erholung bei Sportlern. Int J Sport Nutr Exerc Metab. March 1, 2018;28(2):188-99.  

9 Nanavati K, Rutherfurd-Markwick K, Lee SJ, Bishop NC, Ali A. Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review. Eur J Nutr. 1. Dezember 2022;61(8):3835-55.  

10 Nicol LM, Rowlands DS, Fazakerly R, Kellett J. Curcumin-Supplementierung mildert wahrscheinlich den verzögert auftretenden Muskelkater (DOMS). Eur J Appl Physiol. Aug 1, 2015;115(8):1769-77.  

11 Tsuruta A, Horiike T, Yoshimura M, Nagaoka I. Bewertung der Auswirkungen der Verabreichung eines glucosaminhaltigen Ergänzungsmittels auf Biomarker für den Knorpelstoffwechsel bei Fußballspielern: Eine randomisierte, doppelblinde, placebokontrollierte Studie. Mol Med Rep. October 1, 2018;18(4):3941-8.  

12 Martel-Pelletier J, Boileau C, Pelletier JP, Roughley PJ. Knorpel unter normalen Bedingungen und bei Arthrose. Best Pract Res Clin Rheumatol. 1. April 2008;22(2):351-84.  

13 O'Kane JW, Hutchinson E, Atley LM, Eyre DR. Sportbedingte Unterschiede bei Biomarkern für Knochenresorption und Knorpelabbau bei Ausdauersportlern. Osteoarthritis Knorpel. 1. Januar 2006;14(1):71-6.  

14 Jorge PB, Sprey JWC, Runco GM, Lima MV de, Severino NR, Santili C. Unterschiede bei der Gelenkdegeneration in Abhängigkeit von der Sportart. Rev Bras Ortop. September 2019;54(5):509-15.  

15 Clark KL, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, et al. 24-Wochen-Studie über die Verwendung von Kollagenhydrolysat als Nahrungsergänzungsmittel bei Sportlern mit aktivitätsbedingten Gelenkschmerzen. Curr Med Res Opin. 1. Mai 2008;24(5):1485-96.  

16 Zdzieblik D, Oesser S, Gollhofer A, König D. Verbesserung von aktivitätsbedingten Kniegelenkbeschwerden nach Supplementierung spezifischer Kollagenpeptide. Appl Physiol Nutr Metab. June 2017;42(6):588-95.  

17 Di Cesare Mannelli L, Micheli L, Zanardelli M, Ghelardini C. Niedrig dosiertes natives Typ-II-Kollagen verhindert Schmerzen in einem Osteoarthritis-Modell bei Ratten. BMC Musculoskelet Disord. 1 August 2013;14:228.  

18 Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: Eine randomisierte, kontrollierte Studie. Eurasian J Med. June 2016;48(2):95-101.  

19 Serhan CN, Levy BD. Resolvine bei Entzündungen: Entstehung der pro-resolvierenden Superfamilie von Mediatoren [Internet]. American Society for Clinical Investigation; 2018 [zitiert am 21. November 2022]. Verfügbar unter: https://www.jci.org/articles/view/97943/pdf

20. Corder KE, Newsham KR, McDaniel JL, Ezekiel UR, Weiss EP. Auswirkungen einer kurzzeitigen Docosahexaensäure-Supplementierung auf Entzündungsmarker nach exzentrischem Krafttraining bei Frauen. J Sports Sci Med. März 2016;15(1):176-83.  

21 Jouris KB, McDaniel JL, Weiss EP. Die Wirkung einer Omega-3-Fettsäure-Supplementierung auf die Entzündungsreaktion bei exzentrischem Krafttraining. J Sports Sci Med. 2011;10(3):432-8.  

22 Walsh NP. Ernährung und Gesundheit des Immunsystems von Sportlern: Neue Perspektiven für ein altes Paradigma. Sports Med. December 2019;49(S2):153-68.  

23 Zoppi CC, Hohl R, Silva FC, Lazarim FL, Neto JA, Stancanneli M, et al. Auswirkungen einer Vitamin C- und E-Supplementierung bei Profifußballern, die regelmäßig trainieren. J Int Soc Sports Nutr. 1. Dezember 2006;3(2):37.  

24 Heaton LE, Davis JK, Rawson ES, Nuccio RP, Witard OC, Stein KW, et al. Ausgewählte Ernährungsstrategien während der Saison zur Verbesserung der Regeneration von Mannschaftssportlern: Ein praktischer Überblick. Sports Med. November 2017;47(11):2201-18.  

25 Li G, Cheng T, Yu X. Der Einfluss von Spurenelementen auf Osteoarthritis. Front Med [Internet]. 2021 [zitiert am 21. November 2022];8. Verfügbar unter: https://www.frontiersin.org/articles/10.3389/fmed.2021.771297

26. Das A, Hammad TA. Wirksamkeit einer Kombination aus FCHG49 Glucosaminhydrochlorid, TRH122 niedermolekularem Natriumchondroitinsulfat und Manganascorbat bei der Behandlung von Kniearthrose. Osteoarthritis Cartilage September 2000;8(5):343-50.  

27 Wei M, Huang Q, Dai Y, Zhou H, Cui Y, Song W, et al. Koexposition von Mangan, Eisen, Kupfer und Selen und Osteoporoserisiko bei chinesischen Erwachsenen. J Trace Elem Med Biol Organ Soc Miner Trace Elem GMS. Juli 2022;72:126989.  

28 Lin R, Deng C, Li X, Liu Y, Zhang M, Qin C, et al. In Kupfer eingebettete bioaktive Glaskeramiken, die einen entzündungshemmenden Phänotyp und die Regeneration der Knorpel-Knochen-Grenzfläche induzieren. Theranostik. 2019;9(21):6300-13.  

29 Barreca D, Gattuso G, Bellocco E, Calderaro A, Trombetta D, Smeriglio A, et al. Flavanone: Phytochemischer Stoff aus Zitrusfrüchten mit gesundheitsfördernden Eigenschaften. Bio-Faktoren. 2017;43(4):495-506.  

30 Mas-Capdevila A, Teichenne J, Domenech-Coca C, Caimari A, Del Bas JM, Escoté X, et al. Wirkung von Hesperidin auf Risikofaktoren für Herz-Kreislauf-Erkrankungen: Die Rolle der intestinalen Mikrobiota für die Bioverfügbarkeit von Hesperidin. Nährstoffe. 2020;12(5):1488.  

31 Xiong H, Wang J, Ran Q, Lou G, Peng C, Gan Q, et al. Hesperidin: Ein therapeutisches Mittel gegen Fettleibigkeit. Drug Devel Ther. 2019;13:3855-66.  

32 Tejada S, Pinya S, Martorell M, Capó X, Tur JA, Pons A, et al. Potenzielle entzündungshemmende Wirkung von Hesperidin aus der Gattung Citrus. Curr Med Chem. 2018;25(37):4929-45.  

33 Hajialyani M, Hosein Farzaei M, Echeverría J, Nabavi SM, Uriarte E, Sobarzo-Sánchez E. Hesperidin als neuroprotektives Mittel: Ein Überblick über tierexperimentelle und klinische Nachweise. Moleküle. 2019;24(3).  

34 Li C, Schluesener H. Gesundheitsfördernde Wirkungen des Zitrusflavanons Hesperidin. Crit Rev Food Sci Nutr. 2017;57(3):613-31.  

35 Li Y, Kandhare AD, Mukherjee AA, Bodhankar SL. Studien zur akuten und subchronischen oralen Toxizität von aus Orangenschalenextrakt isoliertem Hesperidin bei Sprague-Dawley-Ratten. Regul Toxicol Pharmacol. 2019;105:77-85.  

36 Estruel-Amades S, Massot-Cladera M, Pérez-Cano FJ, Franch À, Castell M, Camps-Bossacoma M. Hesperidin Effects on Gut Microbiota and Gut-Associated Lymphoid Tissue in Healthy Rats. Nährstoffe. 2019;11(2).  

37 Camps-Bossacoma M, Franch À, Pérez-Cano FJ, Castell M. Einfluss von Hesperidin auf die systemische und intestinale Immunantwort der Ratte. Nährstoffe. 2017;9(6).  

38 Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Hesperidin-Supplementierung mildert oxidative DNA-Schäden und Lipidperoxidation bei Typ-2-Diabetes: Eine randomisierte, doppelblinde, placebokontrollierte klinische Studie. Phytother Res. 2017;31(10):1539-45.  

39 Crimaldi S, Liguori S, Tamburrino P, Moretti A, Paoletta M, Toro G, et al. Die Rolle der Hyaluronsäure bei sportbedingten Tendinopathien: Ein narrativer Rückblick. Medizin (Mex). Oct 12, 2021;57(10):1088.  

40 Oe M, Tashiro T, Yoshida H, Nishiyama H, Masuda Y, Maruyama K, et al. Hyaluronan zum Einnehmen lindert Knieschmerzen: eine Übersicht. Nutr J. 27 January 2016;15:11.  

41 Moskowitz RW. Ergänzung mit Hyaluronsäure. Curr Rheumatol Rep. Dezember 2000;2(6):466-71.  

42 Wang SJ, Wang YH, Huang LC. Die Wirkung von oral verabreichter flüssiger Hyaluronsäure mit niedrigem Molekulargewicht in Kombination mit Glucosamin und Chondroitin bei Patienten mit Kniearthrose und leichten Knieschmerzen: Eine 8-wöchige randomisierte, doppelblinde, placebokontrollierte Studie. Medizin (Baltimore). 5. Februar 2021;100(5):e24252.